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Casirivimab/imdevimab study #11   All Outcomes
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ ICU admission 89% Imp. Relative Risk, 95% CI Oxygen therapy 85% Hospitalization 75% Bierle: Monoclonal Antibody Treatment of Breakthrough COVID-19 i.. c19regn.com/bierle.html Favors casiri/imdevimab Favors control
10/20 Early treatment study
Bierle et al., The Journal of Infectious Diseases, doi:10.1093/infdis/jiab570 (preprint 10/20/2021) (Peer Reviewed)
Monoclonal Antibody Treatment of Breakthrough COVID-19 in Fully Vaccinated Individuals with High-Risk Comorbidities
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Retrospective 1,395 vaccinated COVID-19 cases, showing significantly lower hospitalization and oxygen supplementation with monoclonal antibody treatment, primarily casirivimab-imdevimab. Hospitalization was significantly associated with comorbidities.
risk of ICU admission, 88.9% lower, RR 0.11, p = 0.16, treatment 0 of 527 (0.0%), control 5 of 868 (0.6%), relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of oxygen therapy, 85.3% lower, RR 0.15, p < 0.001, treatment 5 of 527 (0.9%), control 56 of 868 (6.5%), odds ratio converted to relative risk.
risk of hospitalization, 75.3% lower, RR 0.25, p < 0.001, treatment 14 of 527 (2.7%), control 93 of 868 (10.7%), odds ratio converted to relative risk.
This study is excluded: patients were treated with different medications, results specific to each medication were not reported.
Conflicts of interest: research funding from the drug patent holder.
Bierle et al., 10/20/2021, retrospective, USA, North America, peer-reviewed, 7 authors.
Contact: razonable.raymund@mayo.edu.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical significance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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