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0 0.5 1 1.5 2+ Ventilation 77% Improvement Relative Risk ICU admission 92% Progression 68% primary Hospitalization time 29% c19regn.com Komagamine et al. Casirivimab/i.. for COVID-19 EARLY Favors casirivimab/im.. Favors control
Komagamine, 128 patient casirivimab/imdevimab early treatment study: 92% lower ICU admission [p=0.04], 68% lower progression [p=0.006], and 29% shorter hospitalization [p=0.001] https://c19p.org/komagamine
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The effect of casirivimab with imdevimab on disease progression in nonsevere COVID‐19 patients in a single hospital in Japan
Komagamine et al., Journal of General and Family Medicine, doi:10.1002/jgf2.516
19 Dec 2021    Source   PDF   Share   Tweet
Combined retrospective/prospective study in Japan with 53 casirivimab/imdevimab patients and 75 control patients, showing significantly lower progression with treatment.
Efficacy is variant dependent. Unlikely to be effective for omicron [Liu, Sheward, Tatham, VanBlargan].
risk of mechanical ventilation, 77.3% lower, RR 0.23, p = 0.51, treatment 0 of 53 (0.0%), control 2 of 75 (2.7%), NNT 38, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of ICU admission, 92.3% lower, RR 0.08, p = 0.04, treatment 0 of 53 (0.0%), control 7 of 75 (9.3%), NNT 11, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of progression, 67.8% lower, RR 0.32, p = 0.006, treatment 8 of 53 (15.1%), control 33 of 75 (44.0%), NNT 3.5, adjusted per study, odds ratio converted to relative risk, multivariable, primary outcome.
hospitalization time, 28.9% lower, relative time 0.71, p < 0.001, treatment 53, control 75.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Komagamine et al., 12/19/2021, retrospective, Japan, Asia, peer-reviewed, 4 authors, average treatment delay 5.0 days.
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