Miyashita, 922 patient casirivimab/imdevimab early treatment study: 46% lower need for oxygen therapy [p=0.004] https://c19p.org/miyashita
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Clinical efficacy of casirivimab-imdevimab antibody combination treatment in patients with COVID-19 Delta variant
et al., Journal of Infection and Chemotherapy, doi:10.1016/j.jiac.2022.05.012
Retrospective 461 patients treated with casirivimab/imdevimab in Japan, and 461 matched controls, showing lower oxygen requirements with treatment.Efficacy is variant dependent. Unlikely to be effective for omicron [Liu, Sheward, Tatham, VanBlargan].
1.
Liu et al., bioRxiv, doi:10.1101/2021.12.14.472719,
Striking Antibody Evasion Manifested by the Omicron Variant of SARS-CoV-2,
https://www.biorxiv.org/content/10.1101/2021.12.14.472719.
2.
Sheward et al., bioRxiv, doi:10.1101/2021.12.19.473354,
Variable loss of antibody potency against SARS-CoV-2 B.1.1.529 (Omicron),
https://www.biorxiv.org/content/10.1101/2021.12.19.473354.
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risk of mechanical ventilation, 33.3% lower, RR 0.67, p = 1.00, treatment 2 of 461 (0.4%), control 3 of 461 (0.7%), NNT 461.
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risk of oxygen therapy, 46.4% lower, RR 0.54, p = 0.004, treatment 30 of 461 (6.5%), control 56 of 461 (12.1%), NNT 18.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Miyashita et al., 5/26/2022, retrospective, Japan, Asia, peer-reviewed, 6 authors, average treatment delay 4.0 days.
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