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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Hospitalization 85% Improvement Relative Risk Hospitalization/ER 92% Symptomatic case 33% primary Weeks with high viral l.. 40% c19regn.com O'Brien et al. Casirivimab/i.. for COVID-19 RCT EARLY Favors casirivimab/im.. Favors control
O'Brien, 204 patient casirivimab/imdevimab early treatment RCT: 85% lower hospitalization [p=0.25], 92% fewer combined hospitalization/ER visits [p=0.03], 33% fewer symptomatic cases [p=0.04], and 40% improved viral clearance [p=0.001] https://c19p.org/obrien2
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Effect of Subcutaneous Casirivimab and Imdevimab Antibody Combination vs Placebo on Development of Symptomatic COVID-19 in Early Asymptomatic SARS-CoV-2 Infection: A Randomized Clinical Trial
O'Brien et al., JAMA, doi:10.1001/jama.2021.24939768
14 Jan 2022    Source   PDF   Share   Tweet
RCT 204 asymptomatic COVID+ patients, 100 treated with subcutaneous casirivimab/imdevimab, showing lower development of symptoms, lower hospitalization, and faster viral clearance with treatment. Study conducted prior to widespread circulation of delta and omicron in the study locations.
Efficacy is variant dependent. Unlikely to be effective for omicron [Liu, Sheward, Tatham, VanBlargan].
risk of hospitalization, 85.5% lower, RR 0.15, p = 0.25, treatment 0 of 100 (0.0%), control 3 of 104 (2.9%), NNT 35, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of hospitalization/ER, 92.2% lower, RR 0.08, p = 0.03, treatment 0 of 100 (0.0%), control 6 of 104 (5.8%), NNT 17, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of symptomatic case, 33.0% lower, RR 0.67, p = 0.04, treatment 29 of 100 (29.0%), control 44 of 104 (42.3%), NNT 7.5, odds ratio converted to relative risk, day 14, primary outcome.
relative weeks with high viral load, 39.7% better, RR 0.60, p = 0.001, treatment 100, control 104.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
O'Brien et al., 1/14/2022, Double Blind Randomized Controlled Trial, placebo-controlled, multiple countries, multiple regions, peer-reviewed, 38 authors, study period 13 July, 2020 - 28 January, 2021.
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