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0 0.5 1 1.5 2+ Mortality 6% Improvement Relative Risk Ventilation -1% Mortality (b) 21% Ventilation (b) 13% c19regn.com Horby et al. Casirivimab/i.. for COVID-19 RCT LATE Favors casirivimab/im.. Favors control
Horby, 9,785 patient casirivimab/imdevimab late treatment RCT: 6% lower mortality [p=0.16] and 1% higher ventilation [p=0.88] https://c19p.org/recoveryr
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Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Horby et al., The Lancet, doi:10.1016/S0140-6736(22)00163-5 (preprint 6/16/2021)
16 Jun 2021    Source   PDF   Share   Tweet
RCT 9,785 hospitalized patients in the UK showing lower mortality with casirivimab/imdevimab, with statistical significance reached for baseline seronegative patients.
Efficacy is variant dependent. Unlikely to be effective for omicron [Liu, Sheward, Tatham, VanBlargan].
risk of death, 6.0% lower, RR 0.94, p = 0.16, treatment 943 of 4,839 (19.5%), control 1,029 of 4,946 (20.8%), NNT 76, all patients.
risk of mechanical ventilation, 1.0% higher, RR 1.01, p = 0.88, treatment 484 of 4,556 (10.6%), control 488 of 4,642 (10.5%), all patients.
risk of death, 21.0% lower, RR 0.79, p = 0.001, treatment 396 of 1,633 (24.2%), control 452 of 1,520 (29.7%), NNT 18, seronegative patients.
risk of mechanical ventilation, 13.0% lower, RR 0.87, p = 0.13, treatment 190 of 1,599 (11.9%), control 202 of 1,484 (13.6%), NNT 58, seronegative patients.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Horby et al., 6/16/2021, Randomized Controlled Trial, United Kingdom, Europe, peer-reviewed, 32 authors, study period 18 September, 2020 - 22 May, 2021, average treatment delay 9.0 days.
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Late treatment
is less effective
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