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0 0.5 1 1.5 2+ Severe case -46% Improvement Relative Risk c19regn.com Shopen et al. Casirivimab/i.. for COVID-19 EARLY Favors casirivimab/im.. Favors control
Shopen, 359 patient casirivimab/imdevimab early treatment study: 46% higher severe cases [p=0.26] https://c19p.org/shopen
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Doubtful Clinical Benefit of Casirivimab-Imdevimab Treatment for Disease Severity Outcome of High-Risk Patients with SARS-CoV-2 Delta Variant Infection
Shopen et al., medRxiv, doi:10.1101/2022.01.29.22270090 (Preprint)
31 Jan 2022    Source   PDF   Share   Tweet
Retrospective 359 COVID+ patients in Israel, 116 treated with casirivimab/imdevimab, showing no significant difference with treatment in multivariable analysis.
Efficacy is variant dependent. Unlikely to be effective for omicron [Liu, Sheward, Tatham, VanBlargan].
risk of severe case, 45.6% higher, RR 1.46, p = 0.26, treatment 24 of 116 (20.7%), control 26 of 243 (10.7%), adjusted per study, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Shopen et al., 1/31/2022, retrospective, Israel, Middle East, preprint, 11 authors, study period June 2021 - September 2021.
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