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0 0.5 1 1.5 2+ Mortality 36% Improvement Relative Risk Mortality (b) 56% Mortality (c) 21% Death/intubation 31% Discharge 29% c19regn.com Somersan-Karakaya et al. NCT04426695 Casirivimab/i.. RCT LATE Favors casirivimab/im.. Favors control
Somersan-Karakaya, 1,197 patient casirivimab/imdevimab late treatment RCT: 36% lower mortality [p=0.02], 31% lower combined mortality/intubation [p=0.03], and 29% higher hospital discharge [p=0.03] https://c19p.org/somersankarakaya
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REGEN-COV for the Treatment of Hospitalized Patients with Covid-19
Somersan-Karakaya et al., medRxiv, doi:10.1101/2021.11.05.21265656 (Preprint)
8 Nov 2021    Source   PDF   Share   Tweet
RCT 1,336 hospitalized patients with symptom onset <=10 days on low-flow or no supplemental oxygen, showing lower mortality with treatment. Cohorts 2&3 were paused mid-trial due to increased deaths in the treatment arm and these results were not included. NCT04426695.
Efficacy is variant dependent. Unlikely to be effective for omicron [Liu, Sheward, Tatham, VanBlargan].
risk of death, 35.9% lower, RR 0.64, p = 0.02, treatment 59 of 804 (7.3%), control 45 of 393 (11.5%), NNT 24, day 28, mFAS.
risk of death, 55.6% lower, RR 0.44, p = 0.005, treatment 24 of 360 (6.7%), control 24 of 160 (15.0%), NNT 12, seronegative, day 28, mFAS.
risk of death, 21.3% lower, RR 0.79, p = 0.42, treatment 26 of 369 (7.0%), control 18 of 201 (9.0%), NNT 52, seropositive, day 28, mFAS.
risk of death/intubation, 30.9% lower, RR 0.69, p = 0.03, treatment 82 of 804 (10.2%), control 58 of 393 (14.8%), NNT 22, day 1-29, mFAS.
risk of no hospital discharge, 28.6% lower, RR 0.71, p = 0.03, treatment 92 of 804 (11.4%), control 63 of 393 (16.0%), NNT 22, day 1-29, mFAS.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Conflicts of interest: research funding from the drug patent holder, employee of the drug patent holder.
Somersan-Karakaya et al., 11/8/2021, Double Blind Randomized Controlled Trial, multiple countries, multiple regions, preprint, 31 authors, average treatment delay 6.0 days, trial NCT04426695.
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Late treatment
is less effective
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