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0 0.5 1 1.5 2+ Death/hospitalization 61% Improvement Relative Risk Hospitalization 61% c19regn.com Wei et al. Casirivimab/i.. for COVID-19 EARLY Favors casirivimab/im.. Favors control
Wei, 19,564 patient casirivimab/imdevimab early treatment study: 61% lower combined mortality/hospitalization [p<0.0001] and 61% lower hospitalization [p<0.0001] https://c19p.org/wei
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Real-world Effectiveness of Casirivimab and Imdevimab in Patients With COVID-19 in the Ambulatory Setting: An Analysis of Two Large US National Claims Databases
Wei et al., medRxiv, doi:10.1101/2022.02.28.22270796 (Preprint)
28 Feb 2022    Source   PDF   Share   Tweet
Retrospective 4,396 casirivimab/imdevimab patients in the USA, showing lower combined mortality/hospitalization (CDM database) and lower hospitalization (PMTX+ database) with treatment.
Efficacy is variant dependent. Unlikely to be effective for omicron [Liu, Sheward, Tatham, VanBlargan].
risk of death/hospitalization, 61.0% lower, HR 0.39, p < 0.001, treatment 23 of 1,116 (2.1%), control 27 of 5,291 (0.5%), Optum CDM, Cox proportional hazards.
risk of hospitalization, 61.0% lower, HR 0.39, p < 0.001, treatment 59 of 3,280 (1.8%), control 75 of 16,284 (0.5%), IQVIA PMTX+, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Wei et al., 2/28/2022, retrospective, database analysis, USA, North America, preprint, 8 authors, study period December 2020 - June 2021.
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