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Casirivimab/imdevimab study #4   All Outcomes
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Symptomatic case 94% Imp. Relative Risk, 95% CI Case 48% Regeneron: Regeneron Reports Positive Interim Data with REGEN-COV™ .. c19regn.com/regeneron2.html Favors casiri/imdevimab Favors control
1/26 Prophylaxis study
Regeneron Press Release (Preprint)
Regeneron Reports Positive Interim Data with REGEN-COV™ Antibody Cocktail used as Passive Vaccine to Prevent COVID-19
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Interim results of REGEN-COV prophylaxis showing 100% prevention of symptomatic infection (8/223 placebo vs. 0/186 REGEN-COV), and approximately 50% lower overall rates of infection (symptomatic and asymptomatic) (23/223 placebo vs. 10/186 REGEN-COV).
risk of symptomatic case, 93.6% lower, RR 0.06, p = 0.009, treatment 0 of 186 (0.0%), control 8 of 223 (3.6%), relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of case, 47.9% lower, RR 0.52, p = 0.07, treatment 10 of 186 (5.4%), control 23 of 223 (10.3%).
Regeneron et al., 1/26/2021, Randomized Controlled Trial, USA, North America, preprint, 1 author.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical significance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
All Studies   All Outcomes
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