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Casirivimab/imdevimab study #5   All Outcomes
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Death/hospitalization 71% Imp. Relative Risk, 95% CI Death/hospitalization (b) 70% Recovery time 29% Recovery time (b) 29% Regeneron: New phase III data shows investigational antibody cockta.. c19regn.com/regeneron3.html Favors casiri/imdevimab Favors control
3/23 Early treatment study
Regeneron Press Release (Preprint)
New phase III data shows investigational antibody cocktail casirivimab and imdevimab reduced hospitalisation or death by 70% in non-hospitalised patients with COVID-19
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Press release for new phase III data showing lower hospitalization/mortality, and faster symptom resolution among the subset of patients with at least one risk factor.
Some variants may escape antibodies [1].
risk of death/hospitalization, 71.3% lower, RR 0.29, p < 0.001, treatment 18 of 1,355 (1.3%), control 62 of 1,341 (4.6%), 2,400mg IV, >=1 risk factor.
risk of death/hospitalization, 70.4% lower, RR 0.30, p = 0.003, treatment 7 of 736 (1.0%), control 24 of 748 (3.2%), 1,200mg IV, >=1 risk factor.
recovery time, 28.6% lower, relative time 0.71, p < 0.001, treatment 1,355, control 1,341, 2,400mg IV, >=1 risk factor.
recovery time, 28.6% lower, relative time 0.71, p < 0.001, treatment 736, control 748, 1,200mg IV, >=1 risk factor.
Regeneron et al., 3/23/2021, Randomized Controlled Trial, USA, North America, preprint, 1 author.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical significance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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